looks like wx-widgets 2.8 to 3.0 moved the distro path, this comes back clean: ./configure --with-boost=/opt/local/include --with-wx-config=/opt/local/Library/Frameworks/wxWidgets.framework/Versions/wxWidgets/3.0/bin/wx-config --with-wx-prefix=/opt/local/Library/Frameworks/wxWidgets.framework/Versions/wxWidgets/3.0

Thanks dangjavageek and nccb! I've gone through this process a few times as well as nccb's workaround for the configure.ac file. Either way, I get error messages. Following these steps, I get all the way to make and sudo make install and get this error message: clang: error: no such file or directory: '/opt/local/lib/libboost_thread-mt.a' clang: error: no such file or directory: '/opt/local/lib/libboost_atomic-mt.a' Contrastingly, when I've made the changes to the configure.ac file, I get this message: 4: INTERNAL ERROR: recursive push_string! autom4te: /usr/bin/m4 failed with exit status: 1 make: *** Error 1 This is what happens when I run autoreconf -i: $ autoreconf -i /Applications/Xcode.app/Contents/Developer/Toolchains/XcodeDefault.xctoolchain/usr/bin/m4: INTERNAL ERROR: recursive push_string! autom4te: /usr/bin/m4 failed with exit status: 1 aclocal: error: echo failed with exit status: 1 autoreconf: /opt/local/bin/aclocal failed with exit status: 1 Any thoughts?